Recombinant DKK1 anticorps

N° du produit ABIN7127455

Cet anticorps anti-DKK1 est un anticorps Lapin Monoclonal détectant DKK1 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour Recombinant DKK1 anticorps (ABIN7127455)

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp DKK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1D12

Détail du produit anti-DKK1 anticorps

Fonction: DKK1 Recombinant Monoclonal Antibody

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human DKK1

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DKK1

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Autre désignation: DKK1

Sujet:

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Aliases: Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1

UniProt: O94907

Pathways: Signalisation WNT, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation